Grading for Level of Evidence
The level of evidence is based on published evidence from studies in FRDA. If there is no published evidence in FRDA, evidence from other like conditions or clinical expertise may have been used to make the recommendation – this is graded as ‘very low’ or in some cases ‘low’ level evidence. See the table below for an explanation of the symbols used to grade recommendations.
| Level of Evidence | Symbol |
| High | ⨁⨁⨁⨁ |
| Moderate | ⨁⨁⨁◯ |
| Low | ⨁⨁◯◯ |
| Very low | ⨁◯◯◯ |
Grading for Strength of Recommendation
For the rating of the strength of the recommendation, in addition to evidence from studies in FRDA, evidence from like conditions, clinical experience and expert consensus are taken into account when published evidence is not available.
| Strength of Recommendation | Symbol |
| Strong for intervention | ↑↑ |
| Conditional for intervention | ↑ |
| Neither intervention nor comparison | — |
| Conditional against intervention | ↓ |
| Strong against intervention | ↓↓ |