Clinical Management Guidelines for Friedreich Ataxia (FRDA)

Topic 5.3. Strategies for fluid and operative management – early mobilization

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This chapter of the Clinical Management Guidelines for Friedreich Ataxia and the recommendations and best practice statements contained herein were endorsed by the authors and the Friedreich Ataxia Guidelines Panel in 2022.

Topic Contents

5.3 Strategies for fluid and operative management – early mobilization

Disclaimer / Intended Use / Funding

Disclaimer
The Clinical Management Guidelines for Friedreich ataxia (‘Guidelines’) are protected by copyright owned by the authors who contributed to their development or said authors’ assignees.

These Guidelines are systematically developed evidence statements incorporating data from a comprehensive literature review of the most recent studies available (up to the Guidelines submission date) and reviewed according to the Grading of Recommendations, Assessment Development and Evaluations (GRADE) framework © The Grade Working Group.

Guidelines users must seek out the most recent information that might supersede the diagnostic and treatment recommendations contained within these Guidelines and consider local variations in clinical settings, funding and resources that may impact on the implementation of the recommendations set out in these Guidelines.

The authors of these Guidelines disclaim all liability for the accuracy or completeness of the Guidelines, and disclaim all warranties, express or implied to their incorrect use.

Intended Use
These Guidelines are made available as general information only and do not constitute medical advice. These Guidelines are intended to assist qualified healthcare professionals make informed treatment decisions about the care of individuals with Friedreich ataxia. They are not intended as a sole source of guidance in managing issues related to Friedreich ataxia. Rather, they are designed to assist clinicians by providing an evidence-based framework for decision-making.

These Guidelines are not intended to replace clinical judgment and other approaches to diagnosing and managing problems associated with Friedreich ataxia which may be appropriate in specific circumstances. Ultimately, healthcare professionals must make their own treatment decisions on a case-by-case basis, after consultation with their patients, using their clinical judgment, knowledge and expertise.
Guidelines users must not edit or modify the Guidelines in any way – including removing any branding, acknowledgement, authorship or copyright notice.

Funding
The authors of this document gratefully acknowledge the support of the Friedreich Ataxia Research Alliance (FARA). The views and opinions expressed in the Guidelines are solely those of the authors and do not necessarily reflect the official policy or position of FARA.


5.3 Strategies for fluid and operative management – early mobilization

Phoebe Sansom

Low mobility levels are prevalent in the hospitalized adult population (5). The negative consequence of prolonged bed rest affecting the cardiovascular, respiratory, gastrointestinal, musculoskeletal, renal, endocrine and nervous systems are well documented (6). Prolonged immobility is associated with adverse outcomes such as functional decline, prolonged length of hospital stay, falls and an increased risk of mortality (5). ‘Standard post-operative management’ in regards to mobilization can vary considerably across settings and institutions. Early mobilization would involve a patient participating in out-of-bed activity as early as possible once deemed medically appropriate.

The complex presentation of individuals with FRDA may affect the confidence of therapists and staff in assessing and mobilizing this cohort, thus placing them at greater risk of low mobility levels in hospital. However, the complex clinical features of FRDA and the decreased strength reserve predispose this population to deconditioning and deterioration in physical functioning with prolonged immobility. Should this occur, the consequences for this already physically compromised population can be devastating.

Early mobilization is recommended to promote maintenance of physical functioning and independence during and after hospitalization. The potential positive effects of early mobilization include maintenance of mobility and physical ability to optimize a return to pre-surgical functional and independence status. Ensuring appropriate physical support and assistance, environmental set-up and equipment requirements both within the hospital setting and after discharge may mitigate the effects of post-surgical immobilization. However, the resources, hospital staff assistance and care-giver support required to facilitate early mobilization need to be considered.


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Please note: Recommendations are systematically developed evidence statements incorporating data from a comprehensive literature review of the most recent studies available (up to the Guidelines submission date) and reviewed according to the Grading of Recommendations, Assessment Development and Evaluations (GRADE) framework © The Grade Working Group. Best Practice Statements are commonly accepted practices, as such formal rating of the quality of evidence by the GRADE process is not indicated. In addition if recommendations from the 2014 guidelines were deemed still relevant, although unable to undergo the scrutiny from a GRADE framework, they were also included as best practice statements.
Early mobilization

QUESTION: Should early/aggressive (out of bed) physical therapy versus standard post-operative management be used for patients undergoing surgery with Friedreich ataxia?

STRENGTH OF RECOMMENDATION:
LEVEL OF EVIDENCE: ⨁◯◯◯

RECOMMENDATION: We suggest early mobilization following surgery over standard post-operative management for individuals with Friedreich ataxia undergoing surgery.

We cannot recommend a particular approach to the timing of getting someone out of bed post-surgery. It is probably best to mobilize as soon as possible with consideration for the following: cardiac/medical status, mobility needs, and decreased reserve of strength.

JUSTIFICATION: The complex clinical features of Friedreich ataxia and the decreased strength reserve predispose this population to deconditioning and deterioration in physical functioning with prolonged immobility. There is no clinical reason to limit early mobilization in the Friedreich ataxia population, other than individual circumstances. Early mobilization is recommended to promote maintenance of physical functioning and independence during and after hospitalization. However, this does not mean there should be early discharge from hospital.

The resources, hospital staff assistance and care-giver support that may be required to allow early mobilization to take place need to be considered.

SUBGROUP CONSIDERATION: This recommendation is for individuals with Friedreich ataxia undergoing surgery. For non-ambulant (hoist transfer dependent) individuals with Friedreich ataxia, a hoist transfer to sit out of bed is a form of mobilization.

Evidence to Recommendation Table PDF

Lay summary of clinical recommendations/best practice statements for surgical and anesthetic considerations in Friedreich ataxia

Why these recommendations/best practice statements?
Friedreich ataxia is often associated with heart problems, scoliosis, diabetes and reduced lung function. This means individuals with Friedreich ataxia may be at greater risk of complications while undergoing surgery than other people.

Particular types of anesthetics and careful monitoring of heart function and fluids may be needed when an individual with Friedreich ataxia has surgery. In addition, surgery and the reduction in activity after surgery may mean a person with Friedreich ataxia will quickly lose physical condition while they recover from the surgery.

What does this mean for you as a person living with Friedreich ataxia or caring for someone living with Friedreich ataxia?
If you are considering surgery it might be important for you to speak with your healthcare professional about Friedreich ataxia and surgery and what it means for you.

We suggest that individuals with Friedreich ataxia considering surgery should be seen by a cardiologist before surgery. In addition, monitoring of heart function should occur during surgery, particularly if there is significant loss of blood or extra fluid is required. Ideally surgery should be done in a center with cardiac intensive care facilities. It is best if mobilization (getting out of bed) commences as soon as possible after surgery.

Health providers may consider a range of anesthetic options for you, including spinal nerve blocks or anesthetics given intravenously.

Who are these recommendations/best practice statements specifically for?
These recommendations and best practice statements are for all individuals with Friedreich ataxia who may be considering or are undergoing surgery.

Phoebe Sansom, BPhysio(Hons), PGCertRehab
Physiotherapist, Monash Health, Melbourne, Victoria, Australia
Email: Phoebe.sansom@monashhealth.org
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These Guidelines are systematically developed evidence statements incorporating data from a comprehensive literature review of the most recent studies available (up to the Guidelines submission date) and reviewed according to the Grading of Recommendations, Assessment Development and Evaluations (GRADE) framework © The Grade Working Group.

This chapter of the Clinical Management Guidelines for Friedreich Ataxia and the recommendations and best practice statements contained herein were endorsed by the authors and the Friedreich Ataxia Guidelines Panel in 2022.

It is our expectation that going forward individual topics can be updated in real-time in response to new evidence versus a re-evaluation and update of all topics simultaneously.

For the rating of the strength of the recommendation, in addition to evidence from studies in FRDA, evidence from like conditions, clinical experience and expert consensus are taken into account when published evidence is not available.

The level of evidence is based on published evidence from studies in FRDA. If there is no published evidence in FRDA, evidence from other like conditions or clinical expertise may have been used to make the recommendation – this is graded as ‘very low’ or in some cases ‘low’ level evidence. See the table below for an explanation of the symbols used to grade recommendations.

Strength of recommendation Symbol Level of evidence Symbol
Strong for intervention ↑↑ High ⨁⨁⨁⨁
Conditional for intervention Moderate ⨁⨁⨁◯
Neither intervention nor comparison Low ⨁⨁◯◯
Conditional against intervention Very low ⨁◯◯◯
Strong against intervention ↓↓
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